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KMID : 0869120150170040341
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기초간호자연과학회지
2015 Volume.17 No. 4 p.341 ~ p.347
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Anti-Inflammatory Effects of Chrysanthemum indicum Water Extract in RAW 264.7 Cell as a Whole Plant
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Kang Kyoung-Ah
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Abstract
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Purpose: Chrysanthemum indicum (CHI) has been used for edible and medical purposes for a long time in Korea. The purpose of this study was to evaluate the anti-inflammatory effects of CHI water extract in lipopolysaccharides (LPS)-induced RAW 264.7 macrophage cells.
Methods: To investigate the anti-inflammatory effects on LPS-induced RAW 264.7 macrophage cells, CHI extract as a whole plant was used in this study. RAW 264.7 cells were treated with various concentrations of CHI extract (1, 10, and ). After that Nitric Oxide (NO), inducible nitric oxide synthase (iNOS), interleukin (IL)-, cyclooxygenase (COX)-2 and prostaglandin () expression level were measured.
Results: CHI extract significantly suppressed the LPS-induced NO production and decreased the level of iNOS, IL-, COX-2 messenger ribonucleic acid (mRNA) expression and also the down regulation of expression in a dose-dependent manner.
Conclusion: The present study suggested that CHI extract can be substituted for anti-inflammatory drugs and provide a safe and effective non pharmacological therapeutic approach.
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KEYWORD
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Anti-inflammation, Chrysanthemum indicum, RAW 264.7 cell,
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